CALRETICULIN-MUTANT PROTEINS INDUCE MEGAKARYOCYTIC SIGNALING TO TRANSFORM HEMATOPOIETIC CELLS AND UNDERGO ACCELERATED DEGRADATION AND GOLGI-MEDIATED SECRETION

Abstract Background Somatic calreticulin (CALR), Janus kinase 2 (JAK2), and thrombopoietin receptor (MPL) mutations essentially show mutual exclusion in myeloproliferative neoplasms (MPN), suggesting that they activate common oncogenic pathways.Recent data have shown that MPL function is essential for CALR mutant-driven MPN.However, the exact role

The present paper deals with the spread of the name C.Iulius among the Thracian sailors in the Roman fleet Pet Accessories in the second century.Analysis of Roman diplomas reveals that C.Iulius was one of the typical military names that soldiers of peregrine origin, such as these Thracians, would take if they had no other preferences.The name had a

Over the recent years, much has been unraveled about the pro-inflammatory properties of various mitochondrial molecules once they are leaving the mitochondrial compartment.On entering the cytoplasm or the extracellular space, mitochondrial DAMPs (also known Rolling Machines as mitochondrial alarmins) can become pro-inflammatory and initiate innate